| PES ID | FIFA ID | # | Player | Nationality | Height | Weight | Strong Foot | Team Name(s) |
|---|---|---|---|---|---|---|---|---|
| 47920 | 219914 | 13 | RB Guillermo Varela | Uruguay | 173cm | 70kg | Right | CR Flamengo, Uruguay |
| 58839 | 216460 | 2 | CB José María Giménez | Uruguay | 185cm | 80kg | Right | Madrid Rosas RB, Uruguay |
| 61525 | - | 10 | AMF G. de Arrascaeta | Uruguay | 172cm | 70kg | Right | CR Flamengo, Uruguay |
| 102895 | 223690 | 1 | GK Sergio Rochet | Uruguay | 190cm | 82kg | Right | SC Internacional, Uruguay |
| 102986 | 224201 | 7 | CF Rodrigo Aguirre | Uruguay | 186cm | 82kg | Left | Club América, Uruguay |
| 104594 | 230965 | 8 | CMF Nahitan Nández | Uruguay | 172cm | 70kg | Right | Free Agents, Uruguay |
| 105297 | 227535 | 6 | DMF Rodrigo Bentancur | Uruguay | 187cm | 72kg | Right | Tottenham WB, Uruguay |
| 109849 | 240716 | 16 | LB Mathías Olivera | Uruguay | 184cm | 78kg | Left | Napoli A, Uruguay |
| 109854 | 240976 | 14 | LB Marcelo Saracchi | Uruguay | 175cm | 69kg | Left | CA Boca Juniors, Uruguay |
| 113911 | 239053 | 15 | CMF Federico Valverde | Uruguay | 182cm | 78kg | Right | Madrid Chamartin B, Uruguay |
| 116576 | 237658 | 19 | CB Santiago Bueno | Uruguay | 190cm | 80kg | Right | Wolverhampton YB, Uruguay |
| 118353 | 240699 | 24 | CMF Nicolás de la Cruz | Uruguay | 167cm | 65kg | Right | CR Flamengo, Uruguay |
| 130927 | 259259 | 23 | GK Santiago Mele | Uruguay | 185cm | 69kg | Right | Free Agents, Uruguay |
| 131722 | - | 26 | DMF Nicolás Fonseca | Uruguay | 181cm | 74kg | Right | Free Agents, Uruguay |
| 132544 | 253163 | 4 | CB Ronald Araújo | Uruguay | 188cm | 79kg | Right | FC Barcelona, Uruguay |
| 133301 | 253072 | 9 | CF Darwin Núñez | Uruguay | 187cm | 81kg | Right | Free Agents, Uruguay |
| 140601 | 258819 | 17 | RWF Cristian Olivera | Uruguay | 170cm | 64kg | Right | Grêmio FBPA, Uruguay |
| 140868 | 253283 | 11 | RWF Facundo Pellistri | Uruguay | 175cm | 65kg | Right | Free Agents, Uruguay |
| 141748 | 270141 | 12 | GK Franco Israel | Uruguay | 190cm | 83kg | Right | Torino G, Uruguay |
| 142410 | 253306 | 5 | DMF Manuel Ugarte | Uruguay | 182cm | 70kg | Right | Manchester United, Uruguay |
| 143071 | - | 18 | LWF Brian Rodríguez | Uruguay | 174cm | 68kg | Right | Club América, Uruguay |
| 145746 | - | 3 | CB Sebastián Cáceres | Uruguay | 180cm | 77kg | Right | Club América, Uruguay |
| 146371 | - | 21 | RWF Facundo Torres | Uruguay | 177cm | 69kg | Left | SE Palmeiras, Uruguay |
| 146559 | - | 22 | LB Joaquín Piquerez | Uruguay | 185cm | 80kg | Left | SE Palmeiras, Uruguay |
| 147895 | 254817 | 20 | LMF Maximiliano Araújo | Uruguay | 179cm | 73kg | Left | Sporting CP, Uruguay |
| 170862 | - | 25 | CF Luciano Rodríguez | Uruguay | 179cm | 75kg | Right | EC Bahia, Uruguay |